Microwave-assisted organic synthesis of nucleoside ProTide analogues

Microwave Assisted Organic Synthesis

Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.

An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Microwave-assisted Domino Reaction in Organic Synthesis

The fields of combinatorial and automated medicinal chemistry have emerged to meet the increasing requirement of new compounds for drug discovery, where speed is of the essence (Loupy, 2002). In this regard, domino (or tandem, or cascade) reactions where “two or more bond-forming transformations take place under the same reaction conditions without adding additional reagents and catalysts, and ...

Microwave-assisted synthesis of molybdenum oxide nanoparticles

This paper focused on a simple approach for synthesis of molybdenum oxide (MoO3) nanoparticles and reports a facile route for synthesis of such nanoparticles, using microwave irradiation as a homogenous and powerful source of heating, using ethylene glycol as the solvent and heating medium. For more investigations, besides microwave heating, the obtained solutions were also treated by conventio...